Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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736
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750
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736
Tocris Bioscience™ Phen Green SK diacetate
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Heavy metal ion indicator, membrane permeable
737
Tocris Bioscience™ GSK 2833503A
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective TRPC6 and TRPC3 antagonist
738
Tocris Bioscience™ Avasimibe
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ACAT inhibitor
739
| CAS | 50-12-4 |
|---|---|
| Molecular Formula | C12H14N2O2 |
740
| CAS | 71320-77-9 |
|---|---|
| Molecular Formula | C13H17ClN2O2 |
741
Tocris Bioscience™ ABT 594 Hydrochloride
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Selective α4β2 nAChR agonist
| CAS | 203564-54-9 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride |
| Recommended Storage | Store at -20°C |
| Synonym | Tebanicline |
| Molecular Formula | C9H11ClN2O.HCL |
| Formula Weight | 235.11 |
742
Tocris Bioscience™ GT 949
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective positive allosteric modulator of EAAT2
| CAS | 460330-27-2 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C30H37N7O2 |
743
Tocris Bioscience™ Aprepitant
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent long-acting hNK-1 antagonist
744
Tocris Bioscience™ Obatoclax Mesylate
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Inhibitor of Bcl-2 family members (IC50 values are 1.11 - 7 μM); antiapoptotic
| CAS | 803712-79-0 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate |
| Recommended Storage | Store at -20°C |
| Synonym | GX15-070 |
| Molecular Formula | C20H19N3O.CH3SO3H |
| Formula Weight | 413.49 |
745
Tocris Bioscience™ AS 99
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Selective ASH1L histone methyltransferase inhibitor
746
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Thermo Scientific Chemicals Alectinib, 95%
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Thermo Scientific Chemicals Alectinib, 95%
CAS: 1256580-46-7 Molecular Formula: C30H34N4O2 Molecular Weight (g/mol): 482.63 InChI Key: KDGFLJKFZUIJMX-UHFFFAOYSA-N IUPAC Name: 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-5H,6H,11H-benzo[b]carbazole-3-carbonitrile SMILES: CCC1=C(C=C2C(=C1)C(=O)C1=C(NC3=CC(=CC=C13)C#N)C2(C)C)N1CCC(CC1)N1CCOCC1
| CAS | 1256580-46-7 |
|---|---|
| Molecular Weight (g/mol) | 482.63 |
| SMILES | CCC1=C(C=C2C(=C1)C(=O)C1=C(NC3=CC(=CC=C13)C#N)C2(C)C)N1CCC(CC1)N1CCOCC1 |
| IUPAC Name | 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-5H,6H,11H-benzo[b]carbazole-3-carbonitrile |
| InChI Key | KDGFLJKFZUIJMX-UHFFFAOYSA-N |
| Molecular Formula | C30H34N4O2 |
747
| CAS | 34157-83-0 |
|---|---|
| Molecular Formula | C29H3804 |
748
Tocris Bioscience™ BAY 390
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Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable
749
Tocris Bioscience™ Pexacerfont
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective CRF1 antagonist; anxiolytic
| CAS | 459856-18-9 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C18H24N6O |
| Formula Weight | 340.43 |
750
Tocris Bioscience™ Ambrisentan
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Selective ETA antagonist